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Dapoxetine HCl
CAS No. 129938-20-1
Dapoxetine HCl( Dapoxetine hydrochloride | LY-210448 hydrochloride | LY-210448 | Priligy )
Catalog No. M19450 CAS No. 129938-20-1
Dapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor used for the therapy of premature ejaculation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 40 | Get Quote |
|
| 50MG | 58 | Get Quote |
|
| 100MG | 87 | Get Quote |
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| 200MG | 140 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameDapoxetine HCl
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NoteResearch use only, not for human use.
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Brief DescriptionDapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor used for the therapy of premature ejaculation.
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DescriptionDapoxetine HCl is a selectivity short-acting serotonin reuptake inhibitor used for the therapy of premature ejaculation.(In Vitro):Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine?dopamine.Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.(In Vivo):Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats.
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In VitroDapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine? dopamine.Dapoxetine hydrochloride inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.
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In VivoDapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats. Animal Model:Adult male Wistar rats Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg Administration:Oral gavage; 1-10 mg/kg; once daily Result:Reverted most of the changes made by testosterone injection
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SynonymsDapoxetine hydrochloride | LY-210448 hydrochloride | LY-210448 | Priligy
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT
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Research AreaNeurological Disease
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IndicationPremature ejaculation
Chemical Information
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CAS Number129938-20-1
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Formula Weight341.87
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Molecular FormulaC21H23NO·HCl
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Purity>98% (HPLC)
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SolubilityDMSO:34.2 mg/mL (100 mM);water:25.6 mg/mL (75 mM)
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SMILESCl.CN(C)[C@@H](CCOc1cccc2ccccc12)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jeong I et al. Neuropharmacology2012 62(7) 2261-2266.
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